However, we are open to utilising any tool or technique be it individual, hybrid, or purely continuum based in order to better capture the complexity of cancer and address the specific aspect under consideration.
The HDC technique is both simple and powerful, allowing discrete individuals and continuous variables to interact at the scales they naturally occur. The Hybrid-Discrete Continuum (HDC) model developed initially in application to nematode movement (1996), and subsequently applied to tumor angiogenes (1998), invasion (2000, 2005, 2006) and Dictyostelium dynamics (2002) is one such multiscale approach. The multiscale nature of cancer requires mathematical modelling approaches of a similar nature. Mathematical models, in general, have suffered greatly due to a lack of true experimental parameterization and derivation with the new Integrated Mathematical Oncology division at Moffitt we hope to address this issue and develop truly integrated models of specific cancers that can have both predictive and therapeutic application.Ĭancer is a complex, multiscale process, in which genetic mutations occurring at a subcellular level manifest themselves as functional changes at the cellular and tissue scale.
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